Select Publications 




Select Publications about SP-2577 and analogs:

High-throughput virtual screening identifies novel N′-(1-phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors.

2013 Journal of medicinal chemistry


Clinical Efficacy of Combined Therapy with LSD1 Antagonist SP-2509 and Pan-Histone Deacetylase Inhibitor Against AML Blast Progenitor Cells.

2012 Blood


Inhibition of LSD1 disrupts global EWS/ETS transcriptional function in Ewing sarcoma.

2014 AACR


Reversible lysine-specific demethylase 1 antagonist HCI-2509 inhibits growth and decreases c-MYC in castration-and docetaxel-resistant prostate cancer cells.

2016 Prostate cancer and prostatic diseases


Select publications about LSD1’s role in cancer:

Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and-independent manners.

2012 ACS chemical biology


Androgen receptor gene expression in prostate cancer is directly suppressed by the androgen receptor through recruitment of lysine-specific demethylase

2011 Cancer cell


GFI1 functions in transcriptional control and cell fate determination require SNAG domain methylation to recruit LSD1

2016 Biochemical Journal


LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

2005 Nature


Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting

2016 Oncotarget


The histone LSD1 demethylase in stemness and cancer transcription programs

2013 Biochimica et Biophysica Acta


Histone demethylase LSD1 controls the phenotypic plasticity of cancer cells

2016 Cancer Science

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